An 18-month-old, male, Italian Pointer was presented with the history of a gradually growing skin tumour-like lesion in the popliteal fossa. Cytology was not definitive but calcinosis circumscripta was suspected based on imaging (mainly X-rays and CT); the final diagnosis was made by histological examination. Surgical excision of the calcified structure led to complete remission of symptoms with no recurrence of the disease within the next 12 months. Several cases of ectopic mineralisation, mainly involving the hind limbs and tongue of young, large-size dogs, are reported in the literature, but, to the Authors’ knowledge, this is the first case of calcinosis circumscripta in a dog’s popliteal fossa.