Chronic enteropathy foodand immunosuppressantresponsive: comparison of clinicopathological findings and follow-up

Introduction and objective - The term chronic enteropathy encompasses various clinical entities with similar etiology, but different therapeutic responses on the basis of which they are retrospectively subdivided. In this work two groups of italian dogs suffering from diet- (food responsive enteropathy, FRE) and immunosuppressant-responsive chronic enteropathy (steroid responsive enteropathy, IRE) were compared, respectively, with two aims: to evaluate possible associations between clinical, clinicopathological marker and diagnosis of FRE/IRE; identify possible clinical, clinicopathological findings predictive of survival and/or relapse in dogs with IRE.
Materials and Methods - Retrospective analysis of medical records of clientowned dogs with a diagnosis of FRE or IRE. Clinical and clinicopathologic findings of the two groups were compared and correlated with the survival time and relapse.
Results - Of the 81 dogs included in the study, 42 were classified as FRE and 39 as IRE. A significant association between a diagnosis of IRE and old age, high CIBDAI/CCECAI scores, small intestine diarrhea, anorexia, weight loss, ascites, hypoalbuminemia, hypoglobulinemia and hypocobalaminemia was found. In addition, a significant association between one relapse at least and death in dogs with IRE was found.
Discussion - Most of the results of this study are consistent with previous observations. The most interesting novelty, is represented by the fact that, regardless the severity of clinical presentation at diagnosis, dogs with IRE that respond to therapy are more likely to live longer.

Additional Info

  • Authors: 1 Bignone I., 1 Tomassone L., 2 Lotti U., 3 Gianella P.
  • Authors note: 1 Dipartimento di Scienze Veterinarie, Università degli Studi di Torino (TO) - 2 Clinica Veterinaria Valdinievole, Monsummano Terme (PT) - 3 Dipartimento di Scienze Veterinarie, Università degli Studi di Torino (TO)
  • Year: 2017
  • Reference: Veterinaria Year 31, n. 4, August 2017
  • Pages: 1 - 8
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