Luxation of the radial carpal bone is an uncommon orthopaedic condition in dogs. Here we describe two cases of radial carpal bone luxation, one in a 7-year old, mixed breed, spayed bitch (case 1), the other in a 9-yearold, mixed breed, neutered male dog (case 2). Both dogs were referred for severe front limb lameness. Physical examination showed a reduced range of motion of the radio-carpal joint and palmaro-medial swelling. Radiographs showed palmaro-medial luxation of the radial carpal bone. In case 1 computed tomography scans did not reveal any other lesions to the radial carpal bone or to the adjacent carpal bones. In case 1 an open reduction of the radial carpal bone was performed, restoring the bone to its anatomic position; the joint capsule was sutured and the limb was immobilized with a splint for 2 weeks. In case 2 a closed reduction was obtained and a transarticular external fixator was applied for 3 weeks. In both cases, at 8 weeks after surgery, the radial carpal bone was still in its anatomic place. The range of motion was partially reduced but no lameness was detected.