Spondylitis is an inflammatory process of the vertebra that may lead to a destructive process with exuberant new bone formation. This condition can produce a distortion of the bone architecture, degenerative joint changes and ankylosis of adjacent vertebra. Reptiles lack intervertebral discs; thus, the term discospondylitis is considered wrong. Histological lesions are categorized as bacterial osteoarthritis related to Salmonella spp. and noninflammatory osteoarthrosis with foci of chronic inflammation that are negative on bacterial culture. In snakes, segmental, proliferative infectious spondylitis has been reported. Gram-negative bacteria (Salmonella sp. and Pseudomonas sp.) are usually isolated from affected bones. Antemortem diagnosis is considered difficult in snakes, and for this reason, the prognosis is considered poor. This report describes the diagnosis and successful treatment of Salmonella enterica ssp. enterica-related infectious spondtis in a pet corn snake (Pantherophis guttatus).